adult thymus: a forgotten jail for autoreactive t cells

Adult Thymus: A Forgotten Jail for Autoreactive T Cells

Forgotten Pages of Jail History

capped by the empiricism and fetichism of the age; sanitary science did not exist; bacteriolgy was unheard of, and the medical world had not yet divorced itself from an impossible classification of disease, which, by its very nature, obscured the issues at stake and directed investigation away from the proper channels. One of Dr. Mouat's most noticeable failings was an undue prolixity, which ev...

Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway.

Despite negative selection in the thymus, significant numbers of autoreactive T cells still escape to the periphery and cause autoimmune diseases when immune regulation goes awry. It is largely unknown how these T cells escape clonal deletion. In this study, we report that CD24 deficiency caused deletion of autoreactive T cells that normally escape negative selection. Restoration of CD24 expres...

Reentry of T cells to the adult thymus is restricted to activated T cells

To seek information on the capacity of mature T cells to migrate to the thymus, mice were injected with Thy-1-marked populations enriched for resting T cells or T blast cells; localization of the donor cells in the host thymus was assessed by staining cryostat sections of thymus and by FACS analysis of cell suspensions. With injection of purified resting T cells, thymic homing was extremely lim...

Autoreactive T and B Cells from Bullous

Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression.

Normal T cell repertoire contains regulatory T cells that control autoimmune responses in the periphery. One recent study demonstrated that CD4(+)CD25(+) T cells were generated from autoreactive T cells without negative selection. However, it is unclear whether, in general, positive selection and negative selection of autoreactive T cells are mutually exclusive processes in the thymus. To inves...